Genes within the Idd5 and Idd9/11 Diabetes Susceptibility Loci affect the Pathogenic Activity of B-cells in NOD mice

Autoreactive T-cells clearly mediate the pancreatic β cell destruction causing Type 1 diabetes (T1D). However, studies in NOD mice indicate that B-cells also contribute to pathogenesis since their ablation by introduction of an Igμ(null) mutation elicits T1D resistance. T1D susceptibility is restore...

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Main Authors: Silveira, Pablo A., Chapman, Harold D., Stolp, Jessica, Johnson, Ellis, Cox, S. Lewis, Hunter, Kara, Wicker, Linda S., Serreze, David V.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2006
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886968/
https://ncbi.nlm.nih.gov/pubmed/17082619
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