B Cell Selection Defects Underlie the Development of Diabetogenic APCs in Nonobese Diabetic Mice()

One mechanism whereby B cells contribute to type 1 diabetes in nonobese diabetic (NOD) mice is as a subset of APCs that preferentially presents MHC class II-bound pancreatic β cell Ags to autoreactive CD4 T cells. This results from their ability to use cell surface Ig to specifically capture β cell...

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Autores principales: Silveira, Pablo A., Dombrowsky, Joseph, Johnson, Ellis, Chapman, Harold D., Nemazee, David, Serreze, David V.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2004
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792717/
https://ncbi.nlm.nih.gov/pubmed/15067092
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