Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor–induced STAT1 activation

Por Bhattacharyya, Sandip, Zhao, Yuxing, Kay, Thomas W. H., Muglia, Louis J.
Publicado em 2011

Insulin teaches a new lesson in tolerance

Por Kay, Thomas W H, Krishnamurthy, Bala, Brodnicki, Thomas C, Mannering, Stuart I
Publicado em 2009

Severe Pancreatitis with Exocrine Destruction and Increased Islet Neogenesis in Mice with Suppressor of Cytokine Signaling-1 Deficiency

Por Chen, Ye, Chong, Mark M.W., Darwiche, Rima, Thomas, Helen E., Kay, Thomas W.H.
Publicado em 2004

Rotavirus Infection Accelerates Type 1 Diabetes in Mice with Established Insulitis

Por Graham, Kate L., Sanders, Natalie, Tan, Yan, Allison, Janette, Kay, Thomas W. H., Coulson, Barbara S.
Publicado em 2008

Lack of Expression of Gp-130 Makes Pancreatic Beta Cell Lines Unresponsive to the IL-6 Family of Cytokines

Por Naselli, Gaetano, Deaizpurua, Henry J., Thomas, Helen E., Johnston, Anne M., Kay, Thomas W. H.
Publicado em 2000

Prevention of “Humanized” Diabetogenic CD8 T-Cell Responses in HLA-Transgenic NOD Mice by a Multipeptide Coupled-Cell Approach

Por Niens, Marijke, Grier, Alexandra E., Marron, Michele, Kay, Thomas W.H., Greiner, Dale L., Serreze, David V.
Publicado em 2011

Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling

Por Pane, Jessica A., Fleming, Fiona E., Graham, Kate L., Thomas, Helen E., Kay, Thomas W. H., Coulson, Barbara S.
Publicado no Sci Rep (2016)

NF-κB is weakly activated in the NOD mouse model of type 1 diabetes

Por Irvin, Allison E., Jhala, Gaurang, Zhao, Yuxing, Blackwell, Timothy S., Krishnamurthy, Balasubramanian, Thomas, Helen E., Kay, Thomas W. H.
Publicado no Sci Rep (2018)

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

Por Coppieters, Ken T., Dotta, Francesco, Amirian, Natalie, Campbell, Peter D., Kay, Thomas W.H., Atkinson, Mark A., Roep, Bart O., von Herrath, Matthias G.
Publicado em 2012

Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes

Por Jhala, Gaurang, Chee, Jonathan, Trivedi, Prerak M., Selck, Claudia, Gurzov, Esteban N., Graham, Kate L., Thomas, Helen E., Kay, Thomas W.H., Krishnamurthy, Balasubramanian
Publicado no JCI Insight (2016)

Pathogenic Mechanisms in Type 1 Diabetes: The Islet is Both Target and Driver of Disease

Por Graham, Kate L., Sutherland, Robyn M., Mannering, Stuart I., Zhao, Yuxing, Chee, Jonathan, Krishnamurthy, Balasubramanian, Thomas, Helen E., Lew, Andrew M., Kay, Thomas W.H.
Publicado em 2012

Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells

Por Krishnamurthy, Balasubramanian, Chee, Jonathan, Jhala, Gaurang, Fynch, Stacey, Graham, Kate L., Santamaria, Pere, Morahan, Grant, Allison, Janette, Izon, David, Thomas, Helen E., Kay, Thomas W.H.
Publicado em 2012

Perturbed thymopoiesis in vitro in the absence of Suppressor of Cytokine Signalling 1 and 3

Por Croom, Hayley A., Izon, David J., Chong, Mark M., Curtis, David J., Roberts, Andrew W., Kay, Thomas W.H., Hilton, Douglas J., Alexander, Warren S., Starr, Robyn
Publicado no Mol Immunol (2008)

Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax

Por McKenzie, Mark D., Jamieson, Emma, Jansen, Elisa S., Scott, Clare L., Huang, David C.S., Bouillet, Philippe, Allison, Janette, Kay, Thomas W.H., Strasser, Andreas, Thomas, Helen E.
Publicado em 2010

Interleukin-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells: Implications for the Timing of Tolerizi...

Por Bertin-Maghit, Sebastien, Pang, Dimeng, O'Sullivan, Brendan, Best, Shannon, Duggan, Emily, Paul, Sanjoy, Thomas, Helen, Kay, Thomas W.H., Harrison, Leonard C., Steptoe, Raymond, Thomas, Ranjeny
Publicado em 2011

Compensatory Mechanisms Allow Undersized Anchor-deficient Class I MHC Ligands to Mediate Pathogenic Autoreactive T Cell Responses()

Por Lamont, Deanna, Mukherjee, Gayatri, Kumar, P. Rajesh, Samanta, Dibyendu, McPhee, Caroline G., Kay, Thomas W. H., Almo, Steven C., DiLorenzo, Teresa P., Serreze, David V.
Publicado em 2014

Lipotoxic Stress Induces Pancreatic β-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System

Por Litwak, Sara A., Wali, Jibran A., Pappas, Evan G., Saadi, Hamdi, Stanley, William J., Varanasi, L. Chitra, Kay, Thomas W. H., Thomas, Helen E., Gurzov, Esteban N.
Publicado no J Diabetes Res (2015)

The insulin A-chain epitope recognized by human T cells is posttranslationally modified

Por Mannering, Stuart I., Harrison, Leonard C., Williamson, Nicholas A., Morris, Jessica S., Thearle, Daniel J., Jensen, Kent P., Kay, Thomas W.H., Rossjohn, Jamie, Falk, Ben A., Nepom, Gerald T., Purcell, Anthony W.
Publicado em 2005

A comparative analysis of high-throughput platforms for validation of a circulating microRNA signature in diabetic retinopathy

Por Farr, Ryan J., Januszewski, Andrzej S., Joglekar, Mugdha V., Liang, Helena, McAulley, Annie K., Hewitt, Alex W., Thomas, Helen E., Loudovaris, Tom, Kay, Thomas W. H., Jenkins, Alicia, Hardikar, Anandwardhan A.
Publicado no Sci Rep (2015)

Understanding and preventing type 1 diabetes through the unique working model of TrialNet

Por Battaglia, Manuela, Anderson, Mark S., Buckner, Jane H., Geyer, Susan M., Gottlieb, Peter A., Kay, Thomas W. H., Lernmark, Åke, Muller, Sarah, Pugliese, Alberto, Roep, Bart O., Greenbaum, Carla J., Peakman, Mark
Publicado no Diabetologia (2017)