The insulin A-chain epitope recognized by human T cells is posttranslationally modified

The autoimmune process that destroys the insulin-producing pancreatic β cells in type 1 diabetes (T1D) is targeted at insulin and its precursor, proinsulin. T cells that recognize the proximal A-chain of human insulin were identified recently in the pancreatic lymph nodes of subjects who had T1D. To...

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Detalhes bibliográficos
Main Authors: Mannering, Stuart I., Harrison, Leonard C., Williamson, Nicholas A., Morris, Jessica S., Thearle, Daniel J., Jensen, Kent P., Kay, Thomas W.H., Rossjohn, Jamie, Falk, Ben A., Nepom, Gerald T., Purcell, Anthony W.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213236/
https://ncbi.nlm.nih.gov/pubmed/16260488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20051251
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