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Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes
High-affinity self-reactive thymocytes are purged in the thymus, and residual self-reactive T cells, which are detectable in healthy subjects, are controlled by peripheral tolerance mechanisms. Breakdown in these mechanisms results in autoimmune disease, but antigen-specific therapy to augment natur...
Uloženo v:
| Vydáno v: | JCI Insight |
|---|---|
| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Clinical Investigation
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5033903/ https://ncbi.nlm.nih.gov/pubmed/27699217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86065 |
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