Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes

High-affinity self-reactive thymocytes are purged in the thymus, and residual self-reactive T cells, which are detectable in healthy subjects, are controlled by peripheral tolerance mechanisms. Breakdown in these mechanisms results in autoimmune disease, but antigen-specific therapy to augment natur...

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Dettagli Bibliografici
Pubblicato in:JCI Insight
Autori principali: Jhala, Gaurang, Chee, Jonathan, Trivedi, Prerak M., Selck, Claudia, Gurzov, Esteban N., Graham, Kate L., Thomas, Helen E., Kay, Thomas W.H., Krishnamurthy, Balasubramanian
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033903/
https://ncbi.nlm.nih.gov/pubmed/27699217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86065
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