Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP

Type 1 diabetes (T1D) is characterized by immune responses against several autoantigens expressed in pancreatic β cells. T cells specific for proinsulin and islet-specific glucose-6-phosphatase catalytic subunit–related protein (IGRP) can induce T1D in NOD mice. However, whether immune responses to...

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Detalhes bibliográficos
Main Authors: Krishnamurthy, Balasubramanian, Dudek, Nadine L., McKenzie, Mark D., Purcell, Anthony W., Brooks, Andrew G., Gellert, Shane, Colman, Peter G., Harrison, Leonard C., Lew, Andrew M., Thomas, Helen E., Kay, Thomas W.H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1679712/
https://ncbi.nlm.nih.gov/pubmed/17143333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29602
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