Autoreactive Cytotoxic T Lymphocytes Acquire Higher Expression of Cytotoxic Effector Markers in the Islets of NOD Mice after Priming in Pancreatic Lymph Nodes

Cytotoxic T lymphocytes (CTLs) that cause type 1 diabetes are activated in draining lymph nodes and become concentrated as fully active CTLs in inflamed pancreatic islets. It is unclear whether CTL function is driven by signals received in the lymph node or also in the inflamed tissue. We studied wh...

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Hlavní autoři: Graham, Kate L., Krishnamurthy, Balasubramanian, Fynch, Stacey, Mollah, Zia U., Slattery, Robyn, Santamaria, Pere, Kay, Thomas W., Thomas, Helen E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2011
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124028/
https://ncbi.nlm.nih.gov/pubmed/21641394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.02.015
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