Autoreactive Cytotoxic T Lymphocytes Acquire Higher Expression of Cytotoxic Effector Markers in the Islets of NOD Mice after Priming in Pancreatic Lymph Nodes

Cytotoxic T lymphocytes (CTLs) that cause type 1 diabetes are activated in draining lymph nodes and become concentrated as fully active CTLs in inflamed pancreatic islets. It is unclear whether CTL function is driven by signals received in the lymph node or also in the inflamed tissue. We studied wh...

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Bibliografiske detaljer
Main Authors: Graham, Kate L., Krishnamurthy, Balasubramanian, Fynch, Stacey, Mollah, Zia U., Slattery, Robyn, Santamaria, Pere, Kay, Thomas W., Thomas, Helen E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2011
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124028/
https://ncbi.nlm.nih.gov/pubmed/21641394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.02.015
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