The Type 1 Diabetes-Resistance locus Idd22 Controls Trafficking of Autoreactive Cytotoxic T Lymphocytes into the Pancreatic Islets of NOD Mice()

Type 1 Diabetes (T1D) has a strong genetic component. The Insulin dependent diabetes 22 (Idd22) locus was identified in crosses of T1D-susceptible NOD mice with the strongly T1D-resistant ALR strain. The NOD-Idd22 recombinant congenic mouse strain was generated where NOD mice carry the full Idd22 co...

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Udgivet i:J Immunol
Main Authors: Whitener, Robert L., Knight, Lisa Gallo, Li, Jianwei, Knapp, Sarah, Zhang, Shuyao, Annamalai, Mani, Pliner, Vadim M, Fu, Dongtao, Radichev, Ilian, Amatya, Christina, Savinov, Alexei, Yurdagul, Arif, Yuan, Shuai, Glawe, John, Kevil, Christopher G., Chen, Jing, Stimpson, Scott E., Mathews, Clayton E
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716886/
https://ncbi.nlm.nih.gov/pubmed/29109122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1602037
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