Autoreactive Effector/Memory CD4(+) and CD8(+) T Cells Infiltrating Grafted and Endogenous Islets in Diabetic NOD Mice Exhibit Similar T Cell Receptor Usage

Islet transplantation provides a “cure” for type 1 diabetes but is limited in part by recurrent autoimmunity mediated by β cell-specific CD4(+) and CD8(+) T cells. Insight into the T cell receptor (TCR) repertoire of effector T cells driving recurrent autoimmunity would aid the development of immuno...

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Bibliographic Details
Main Authors: Diz, Ramiro, Garland, Alaina, Vincent, Benjamin G., Johnson, Mark C., Spidale, Nicholas, Wang, Bo, Tisch, Roland
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522632/
https://ncbi.nlm.nih.gov/pubmed/23251685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052054
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