Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice

T-cell responses to insulin and its precursor proinsulin are central to islet autoimmunity in humans and non-obese diabetic (NOD) mice that spontaneously develop autoimmune diabetes. Mice have two proinsulin genes proinsulin -1 and 2 that are differentially expressed, with predominant proinsulin-2 e...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Jhala, Gaurang, Selck, Claudia, Chee, Jonathan, Kwong, Chun-Ting J., Pappas, Evan G., Thomas, Helen E., Kay, Thomas W.H., Krishnamurthy, Balasubramanian
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027244/
https://ncbi.nlm.nih.gov/pubmed/33841427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.645817
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