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Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice
T-cell responses to insulin and its precursor proinsulin are central to islet autoimmunity in humans and non-obese diabetic (NOD) mice that spontaneously develop autoimmune diabetes. Mice have two proinsulin genes proinsulin -1 and 2 that are differentially expressed, with predominant proinsulin-2 e...
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| Опубликовано в: : | Front Immunol |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Frontiers Media S.A.
2021
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8027244/ https://ncbi.nlm.nih.gov/pubmed/33841427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.645817 |
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