The JAK1 Selective Inhibitor ABT 317 Blocks Signaling Through Interferon-γ and Common γ Chain Cytokine Receptors to Reverse Autoimmune Diabetes in NOD Mice

Cytokines that signal through the JAK-STAT pathway, such as interferon-γ (IFN-γ) and common γ chain cytokines, contribute to the destruction of insulin-secreting β cells by CD8(+) T cells in type 1 diabetes (T1D). We previously showed that JAK1/JAK2 inhibitors reversed autoimmune insulitis in non-ob...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Ge, Tingting, Jhala, Gaurang, Fynch, Stacey, Akazawa, Satoru, Litwak, Sara, Pappas, Evan G., Catterall, Tara, Vakil, Ishan, Long, Andrew J., Olson, Lisa M., Krishnamurthy, Balasubramanian, Kay, Thomas W., Thomas, Helen E.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746546/
https://ncbi.nlm.nih.gov/pubmed/33343569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.588543
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