Granzyme B Is Dispensable in the Development of Diabetes in Non-Obese Diabetic Mice

Pancreatic beta cell destruction in type 1 diabetes is mediated by cytotoxic CD8(+) T lymphoctyes (CTL). Granzyme B is an effector molecule used by CTL to kill target cells. We previously showed that granzyme B-deficient allogeneic CTL inefficiently killed pancreatic islets in vitro. We generated gr...

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Detalhes bibliográficos
Main Authors: Mollah, Zia U., Graham, Kate L., Krishnamurthy, Balasubramanian, Trivedi, Prerak, Brodnicki, Thomas C., Trapani, Joseph A., Kay, Thomas W., Thomas, Helen E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392222/
https://ncbi.nlm.nih.gov/pubmed/22792290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040357
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