Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice

CD8(+) T cells play a central role in beta-cell destruction in type 1 diabetes. CD8(+) T cells use two main effector pathways to kill target cells, perforin plus granzymes and FAS ligand (FASL). We and others have established that in non-obese diabetic (NOD) mice, perforin is the dominant effector m...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Cell Death Discov
Main Authors: Trivedi, Prerak M., Fynch, Stacey, Kennedy, Lucy M., Chee, Jonathan, Krishnamurthy, Balasubramanian, O’Reilly, Lorraine A., Strasser, Andreas, Kay, Thomas W. H., Thomas, Helen E.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6755132/
https://ncbi.nlm.nih.gov/pubmed/31552143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-019-0217-z
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares