Orthogonal gene knock out and activation with a catalytically active Cas9 nuclease

Por Dahlman, James E., Abudayyeh, Omar O., Joung, Julia, Gootenberg, Jonathan S., Zhang, Feng, Konermann, Silvana
Publicado no Nat Biotechnol (2015)

High-resolution interrogation of functional elements in the noncoding genome

Por Sanjana, Neville E., Wright, Jason, Zheng, Kaijie, Shalem, Ophir, Fontanillas, Pierre, Joung, Julia, Cheng, Christine, Regev, Aviv, Zhang, Feng
Publicado no Science (2016)

Genome-scale CRISPR-Cas9 Knockout and Transcriptional Activation Screening

Por Joung, Julia, Konermann, Silvana, Gootenberg, Jonathan S., Abudayyeh, Omar O., Platt, Randall J., Brigham, Mark D., Sanjana, Neville E., Zhang, Feng
Publicado no Nat Protoc (2017)

Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes

Por Chung, Won-Suk, Verghese, Philip B., Chakraborty, Chandrani, Joung, Julia, Hyman, Bradley T., Ulrich, Jason D., Holtzman, David M., Barres, Ben A.
Publicado no Proc Natl Acad Sci U S A (2016)

Discovery and functional characterization of diverse Class 2 CRISPR-Cas systems

Por Shmakov, Sergey, Abudayyeh, Omar O., Makarova, Kira S., Wolf, Yuri I, Gootenberg, Jonathan S., Semenova, Ekaterina, Minakhin, Leonid, Joung, Julia, Konermann, Silvana, Severinov, Konstantin, Zhang, Feng, Koonin, Eugene V.
Publicado no Mol Cell (2015)

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

Por Konermann, Silvana, Brigham, Mark D., Trevino, Alexandro E., Joung, Julia, Abudayyeh, Omar O., Barcena, Clea, Hsu, Patrick D., Habib, Naomi, Gootenberg, Jonathan S., Nishimasu, Hiroshi, Nureki, Osamu, Zhang, Feng
Publicado no Nature (2014)

Cpf1 is a single RNA-guided endonuclease of a Class 2 CRISPR-Cas system

Por Zetsche, Bernd, Gootenberg, Jonathan S., Abudayyeh, Omar O., Slaymaker, Ian M., Makarova, Kira S., Essletzbichler, Patrick, Volz, Sara, Joung, Julia, van der Oost, John, Regev, Aviv, Koonin, Eugene V., Zhang, Feng
Publicado no Cell (2015)

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

Por Chung, Won-Suk, Clarke, Laura E., Wang, Gordon X., Stafford, Benjamin K., Sher, Alexander, Chakraborty, Chandrani, Joung, Julia, Foo, Lynette C., Thompson, Andrew, Chen, Chinfei, Smith, Stephen J., Barres, Ben A.
Publicado em 2013

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

Por Abudayyeh, Omar O., Gootenberg, Jonathan S., Konermann, Silvana, Joung, Julia, Slaymaker, Ian M., Cox, David B.T., Shmakov, Sergey, Makarova, Kira S., Semenova, Ekaterina, Minakhin, Leonid, Severinov, Konstantin, Regev, Aviv, Lander, Eric S., Koonin, Eugene V., Zhang, Feng
Publicado no Science (2016)

RNA targeting with CRISPR-Cas13a

Por Abudayyeh, Omar O., Gootenberg, Jonathan S., Essletzbichler, Patrick, Han, Shuo, Joung, Julia, Belanto, Joseph J., Verdine, Vanessa, Cox, David B.T., Kellner, Max J., Regev, Aviv, Lander, Eric S., Voytas, Daniel F., Ting, Alice Y., Zhang, Feng
Publicado no Nature (2017)

Genome-scale Activation Screen Identifies a LncRNA Locus that Regulates a Gene Neighborhood

Por Joung, Julia, Engreitz, Jesse M., Konermann, Silvana, Abudayyeh, Omar O., Verdine, Vanessa K., Aguet, Francois, Gootenberg, Jonathan S., Sanjana, Neville E., Wright, Jason B., Fulco, Charles P., Tseng, Yuen-Yi, Yoon, Charles H., Boehm, Jesse S., Lander, Eric S., Zhang, Feng
Publicado no Nature (2017)

Nucleic acid detection with CRISPR-Cas13a/C2c2

Por Gootenberg, Jonathan S., Abudayyeh, Omar O., Lee, Jeong Wook, Essletzbichler, Patrick, Dy, Aaron J., Joung, Julia, Verdine, Vanessa, Donghia, Nina, Daringer, Nichole M., Freije, Catherine A., Myhrvold, Cameron, Bhattacharyya, Roby P., Livny, Jonathan, Regev, Aviv, Koonin, Eugene V., Hung, Deborah T., Sabeti, Pardis C., Collins, James J., Zhang, Feng
Publicado no Science (2017)