Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes

The strongest genetic risk factor influencing susceptibility to late-onset Alzheimer’s disease (AD) is apolipoprotein E (APOE) genotype. APOE has three common isoforms in humans, E2, E3, and E4. The presence of two copies of the E4 allele increases risk by ∼12-fold whereas E2 allele is associated wi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chung, Won-Suk, Verghese, Philip B., Chakraborty, Chandrani, Joung, Julia, Hyman, Bradley T., Ulrich, Jason D., Holtzman, David M., Barres, Ben A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018780/
https://ncbi.nlm.nih.gov/pubmed/27559087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609896113
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