Mutational analysis of an archaeal minichromosome maintenance protein exterior hairpin reveals critical residues for helicase activity and DNA binding

Por Brewster, Aaron S, Slaymaker, Ian M, Afif, Samir A, Chen, Xiaojiang S
Publicado em 2010

Rationally engineered Cas9 nucleases with improved specificity

Por Slaymaker, Ian M., Gao, Linyi, Zetsche, Bernd, Scott, David A., Yan, Winston X., Zhang, Feng
Publicado no Science (2015)

Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology

Por Slaymaker, Ian M., Fu, Yang, Toso, Daniel B., Ranatunga, Nimna, Brewster, Aaron, Forsburg, Susan L., Zhou, Z. Hong, Chen, Xiaojiang S.
Publicado em 2013

CRISPR–Cas9 Mediated DNA Unwinding Detected Using Site-Directed Spin Labeling

Por Tangprasertchai, Narin S., Di Felice, Rosa, Zhang, Xiaojun, Slaymaker, Ian M., Reyes, Carolina Vazquez, Jiang, Wei, Rohs, Remo, Qin, Peter Z.
Publicado no ACS Chem Biol (2017)

Crystal structure of Cpf1 in complex with guide RNA and target DNA

Por Yamano, Takashi, Nishimasu, Hiroshi, Zetsche, Bernd, Hirano, Hisato, Slaymaker, Ian M., Li, Yinqing, Fedorova, Iana, Nakane, Takanori, Makarova, Kira S., Koonin, Eugene V., Ishitani, Ryuichiro, Zhang, Feng, Nureki, Osamu
Publicado no Cell (2016)

Cpf1 is a single RNA-guided endonuclease of a Class 2 CRISPR-Cas system

Por Zetsche, Bernd, Gootenberg, Jonathan S., Abudayyeh, Omar O., Slaymaker, Ian M., Makarova, Kira S., Essletzbichler, Patrick, Volz, Sara, Joung, Julia, van der Oost, John, Regev, Aviv, Koonin, Eugene V., Zhang, Feng
Publicado no Cell (2015)

Cas13b is a Type VI-B CRISPR-associated RNA-Guided RNAse differentially regulated by accessory proteins Csx27 and Csx28

Por Smargon, Aaron A., Cox, David B.T., Pyzocha, Neena K., Zheng, Kaijie, Slaymaker, Ian M., Gootenberg, Jonathan S., Abudayyeh, Omar A., Essletzbichler, Patrick, Shmakov, Sergey, Makarova, Kira S., Koonin, Eugene V., Zhang, Feng
Publicado no Mol Cell (2017)

Chd8 mutation leads to autistic-like behaviors and impaired striatal circuits

Por Platt, Randall J., Zhou, Yang, Slaymaker, Ian M., Shetty, Ashwin S., Weisbach, Niels R., Kim, Jin-Ah, Sharma, Jitendra, Desai, Mitul, Sood, Sabina, Kempton, Hannah R., Crabtree, Gerald R., Feng, Guoping, Zhang, Feng
Publicado no Cell Rep (2017)

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

Por Abudayyeh, Omar O., Gootenberg, Jonathan S., Konermann, Silvana, Joung, Julia, Slaymaker, Ian M., Cox, David B.T., Shmakov, Sergey, Makarova, Kira S., Semenova, Ekaterina, Minakhin, Leonid, Severinov, Konstantin, Regev, Aviv, Lander, Eric S., Koonin, Eugene V., Zhang, Feng
Publicado no Science (2016)