Chd8 mutation leads to autistic-like behaviors and impaired striatal circuits

Autism spectrum disorder (ASD) is a heterogeneous disease, but genetically defined models can provide an entry point to studying the molecular underpinnings of this disorder. We generated germline mutant mice with loss-of-function mutations in Chd8, a de novo mutation strongly associated with ASD, a...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Platt, Randall J., Zhou, Yang, Slaymaker, Ian M., Shetty, Ashwin S., Weisbach, Niels R., Kim, Jin-Ah, Sharma, Jitendra, Desai, Mitul, Sood, Sabina, Kempton, Hannah R., Crabtree, Gerald R., Feng, Guoping, Zhang, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5455342/
https://ncbi.nlm.nih.gov/pubmed/28402856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.03.052
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