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Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder
BACKGROUND: SAP90/PSD-95-associated protein 3 (SAPAP3, also DLGAP3 or GKAP3) is an excitatory postsynaptic protein implicated in the pathogenesis of obsessive-compulsive behaviors. In mice, genetic deletion of Sapap3 causes obsessive-compulsive disorder (OCD)-like behaviors that are rescued by stria...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3687030/ https://ncbi.nlm.nih.gov/pubmed/23414593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.01.008 |
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