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Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder

BACKGROUND: SAP90/PSD-95-associated protein 3 (SAPAP3, also DLGAP3 or GKAP3) is an excitatory postsynaptic protein implicated in the pathogenesis of obsessive-compulsive behaviors. In mice, genetic deletion of Sapap3 causes obsessive-compulsive disorder (OCD)-like behaviors that are rescued by stria...

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Bibliografski detalji
Glavni autori: Wan, Yehong, Ade, Kristen, Caffall, Zachary, Ozlu, M. Ilcim, Eroglu, Cagla, Feng, Guoping, Calakos, Nicole
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687030/
https://ncbi.nlm.nih.gov/pubmed/23414593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.01.008
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