Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice

BACKGROUND: Development of treatments for obsessive-compulsive disorder (OCD) is hampered by a lack of mechanistic understanding about this prevalent neuropsychiatric condition. Although circuit changes such as elevated frontostriatal activity are linked to OCD, the underlying molecular signaling th...

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書誌詳細
出版年:Biol Psychiatry
主要な著者: Ade, Kristen K., Wan, Yehong, Hamann, Harold C., O’Hare, Justin K., Guo, Weirui, Quian, Anna, Kumar, Sunil, Bhagat, Srishti, Rodriguiz, Ramona M., Wetsel, William C., Conn, P. Jeffrey, Dzirasa, Kafui, Huber, Kimberly M., Calakos, Nicole
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536332/
https://ncbi.nlm.nih.gov/pubmed/27436084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2016.04.023
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