Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice

BACKGROUND: Development of treatments for obsessive-compulsive disorder (OCD) is hampered by a lack of mechanistic understanding about this prevalent neuropsychiatric condition. Although circuit changes such as elevated frontostriatal activity are linked to OCD, the underlying molecular signaling th...

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Udgivet i:Biol Psychiatry
Main Authors: Ade, Kristen K., Wan, Yehong, Hamann, Harold C., O’Hare, Justin K., Guo, Weirui, Quian, Anna, Kumar, Sunil, Bhagat, Srishti, Rodriguiz, Ramona M., Wetsel, William C., Conn, P. Jeffrey, Dzirasa, Kafui, Huber, Kimberly M., Calakos, Nicole
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536332/
https://ncbi.nlm.nih.gov/pubmed/27436084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2016.04.023
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