Cyclodextrin Induces Calcium-Dependent Lysosomal Exocytosis

af Chen, Fannie W., Li, Chunlei, Ioannou, Yiannis A.
Udgivet 2010

NPC1 late endosomes contain elevated levels of non-esterified (‘free’) fatty acids and an abnormally glycosylated form of the NPC2 protein

af Chen, Fannie W., Gordon, Ronald E., Ioannou, Yiannis A.
Udgivet 2005

Fabry Disease: Preclinical Studies Demonstrate the Effectiveness of α-Galactosidase A Replacement in Enzyme-Deficient Mice

af Ioannou, Yiannis A., Zeidner, Ken M., Gordon, Ronald E., Desnick, Robert J.
Udgivet 2001

PKC Activation in Niemann Pick C1 Cells Restores Subcellular Cholesterol Transport

af Tamari, Farshad, Chen, Fannie W., Li, Chunlei, Chaudhari, Jagrutiben, Ioannou, Yiannis A.
Udgivet 2013

MLN64 Transport to the Late Endosome Is Regulated by Binding to 14-3-3 via a Non-canonical Binding Site

af Liapis, Anastasia, Chen, Fannie W., Davies, Joanna P., Wang, Rong, Ioannou, Yiannis A.
Udgivet 2012

Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann–Pick C1-deficient cells

af Sugimoto, Yuko, Ninomiya, Haruaki, Ohsaki, Yuki, Higaki, Katsumi, Davies, Joanna P., Ioannou, Yiannis A., Ohno, Kousaku
Udgivet 2001

Combined transgenic expression of α-galactosidase and α1,2-fucosyltransferase leads to optimal reduction in the major xenoepitope Galα(1,3)Gal

af Osman, Narin, McKenzie, Ian F. C., Ostenried, Karen, Ioannou, Yiannis A., Desnick, Robert J., Sandrin, Mauro S.
Udgivet 1997

Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles

af Labonté, Eric D., Howles, Philip N., Granholm, Norman A., Rojas, Juan C., Davies, Joanna P., Ioannou, Yiannis A., Hui, David Y.
Udgivet 2007

Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent

af Temel, Ryan E., Brown, J. Mark, Ma, Yinyan, Tang, Weiqing, Rudel, Lawrence L., Ioannou, Yiannis A., Davies, Joanna P., Yu, Liqing
Udgivet 2009

Hepatic Niemann-Pick C1–like 1 regulates biliary cholesterol concentration and is a target of ezetimibe

af Temel, Ryan E., Tang, Weiqing, Ma, Yinyan, Rudel, Lawrence L., Willingham, Mark C., Ioannou, Yiannis A., Davies, Joanna P., Nilsson, Lisa-Mari, Yu, Liqing
Udgivet 2007

Endosomal Accumulation of Toll-Like Receptor 4 Causes Constitutive Secretion of Cytokines and Activation of Signal Transducers and Activators of Transcription in Niemann–Pick Disea...

af Suzuki, Michitaka, Sugimoto, Yuko, Ohsaki, Yuki, Ueno, Makoto, Kato, Shinsuke, Kitamura, Yukisato, Hosokawa, Hiroshi, Davies, Joanna P., Ioannou, Yiannis A., Vanier, Marie T., Ohno, Kousaku, Ninomiya, Haruaki
Udgivet i J Neurosci (2007)

Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1(−/−) mice

af Labonté, Eric D., Camarota, Lisa M., Rojas, Juan C., Jandacek, Ronald J., Gilham, Dean E., Davies, Joanna P., Ioannou, Yiannis A., Tso, Patrick, Hui, David Y., Howles, Philip N.
Udgivet 2008

An “Exacerbate-reverse” Strategy in Yeast Identifies Histone Deacetylase Inhibition as a Correction for Cholesterol and Sphingolipid Transport Defects in Human Niemann-Pick Type C...

af Munkacsi, Andrew B., Chen, Fannie W., Brinkman, Matthew A., Higaki, Katsumi, Gutiérrez, Giselle Domínguez, Chaudhari, Jagruti, Layer, Jacob V., Tong, Amy, Bard, Martin, Boone, Charles, Ioannou, Yiannis A., Sturley, Stephen L.
Udgivet 2011

Normalization of Hepatic Homeostasis in the Npc1(nmf164) Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat

af Munkacsi, Andrew B., Hammond, Natalie, Schneider, Remy T., Senanayake, Dinindu S., Higaki, Katsumi, Lagutin, Kirill, Bloor, Stephen J., Ory, Daniel S., Maue, Robert A., Chen, Fannie W., Hernandez-Ono, Antonio, Dahlson, Nicole, Repa, Joyce J., Ginsberg, Henry N., Ioannou, Yiannis A., Sturley, Stephen L.
Udgivet i J Biol Chem (2017)

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth

af Sangodkar, Jaya, Perl, Abbey, Tohme, Rita, Kiselar, Janna, Kastrinsky, David B., Zaware, Nilesh, Izadmehr, Sudeh, Mazhar, Sahar, Wiredja, Danica D., O’Connor, Caitlin M., Hoon, Divya, Dhawan, Neil S., Schlatzer, Daniela, Yao, Shen, Leonard, Daniel, Borczuk, Alain C., Gokulrangan, Giridharan, Wang, Lifu, Svenson, Elena, Farrington, Caroline C., Yuan, Eric, Avelar, Rita A., Stachnik, Agnes, Smith, Blake, Gidwani, Vickram, Giannini, Heather M., McQuaid, Daniel, McClinch, Kimberly, Wang, Zhizhi, Levine, Alice C., Sears, Rosalie C., Chen, Edward Y., Duan, Qiaonan, Datt, Manish, Haider, Shozeb, Ma’ayan, Avi, DiFeo, Analisa, Sharma, Neelesh, Galsky, Matthew D., Brautigan, David L., Ioannou, Yiannis A., Xu, Wenqing, Chance, Mark R., Ohlmeyer, Michael, Narla, Goutham
Udgivet i J Clin Invest (2017)