Hepatic Niemann-Pick C1–like 1 regulates biliary cholesterol concentration and is a target of ezetimibe

Niemann-Pick C1–like 1 (NPC1L1) is required for cholesterol absorption. Intestinal NPC1L1 appears to be a target of ezetimibe, a cholesterol absorption inhibitor that effectively lowers plasma LDL-cholesterol in humans. However, human liver also expresses NPC1L1. Hepatic function of NPC1L1 was previ...

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Bibliographic Details
Main Authors: Temel, Ryan E., Tang, Weiqing, Ma, Yinyan, Rudel, Lawrence L., Willingham, Mark C., Ioannou, Yiannis A., Davies, Joanna P., Nilsson, Lisa-Mari, Yu, Liqing
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2007
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1888567/
https://ncbi.nlm.nih.gov/pubmed/17571164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30060
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