PKC Activation in Niemann Pick C1 Cells Restores Subcellular Cholesterol Transport

Activation of protein kinase C (PKC) has previously been shown to ameliorate the cholesterol transport defect in Niemann Pick Type C1 (NPC1) cells, presumably by increasing the soluble levels of one of its substrates, vimentin. This activity would then restore the vimentin cycle in these cells and a...

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Bibliographic Details
Main Authors: Tamari, Farshad, Chen, Fannie W., Li, Chunlei, Chaudhari, Jagrutiben, Ioannou, Yiannis A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744505/
https://ncbi.nlm.nih.gov/pubmed/23977398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074169
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