Combined transgenic expression of α-galactosidase and α1,2-fucosyltransferase leads to optimal reduction in the major xenoepitope Galα(1,3)Gal

Hyperacute rejection of pig organs by humans involves the interaction of Galα(1,3)Gal with antibodies and complement. Strategies to reduce the amount of xenoantigen Galα(1,3)Gal were investigated by overexpression of human lysosomal α-galactosidase in cultured porcine cells and transgenic mice. The...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Osman, Narin, McKenzie, Ian F. C., Ostenried, Karen, Ioannou, Yiannis A., Desnick, Robert J., Sandrin, Mauro S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25090/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9405672/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.26.14677
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