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Combined transgenic expression of α-galactosidase and α1,2-fucosyltransferase leads to optimal reduction in the major xenoepitope Galα(1,3)Gal

Hyperacute rejection of pig organs by humans involves the interaction of Galα(1,3)Gal with antibodies and complement. Strategies to reduce the amount of xenoantigen Galα(1,3)Gal were investigated by overexpression of human lysosomal α-galactosidase in cultured porcine cells and transgenic mice. The...

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Bibliografske podrobnosti
Main Authors: Osman, Narin, McKenzie, Ian F. C., Ostenried, Karen, Ioannou, Yiannis A., Desnick, Robert J., Sandrin, Mauro S.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences of the USA 1997
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC25090/
https://ncbi.nlm.nih.gov/pubmed/9405672
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