Splice of Life for Cancer: Missplicing of PPP2R5A by Mutant SF3B1 Leads to MYC Stabilization and Tumorigenesis

door O’Connor, Caitlin M., Narla, Goutham
Gepubliceerd in Cancer Discov (2020)

Therapeutic Targeting of PP2A

door O’Connor, Caitlin M., Perl, Abbey, Leonard, Daniel, Sangodkar, Jaya, Narla, Goutham
Gepubliceerd in Int J Biochem Cell Biol (2017)

Protein phosphatase 2A Aα regulates Aβ protein expression and stability

door O'Connor, Caitlin M., Hoffa, Matthew T., Taylor, Sarah E., Avelar, Rita A., Narla, Goutham
Gepubliceerd in J Biol Chem (2019)

Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45)

door Perl, Abbey L., O'Connor, Caitlin M., Fa, Pengyan, Mayca Pozo, Franklin, Zhang, Junran, Zhang, Youwei, Narla, Goutham
Gepubliceerd in J Biol Chem (2019)

Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors

door O’Connor, Caitlin M., Leonard, Daniel, Wiredja, Danica, Avelar, Rita A., Wang, Zhizhi, Schlatzer, Daniela, Bryson, Benjamin, Tokala, Eesha, Taylor, Sarah E., Upadhyay, Aditya, Sangodkar, Jaya, Gingras, Anne-Claude, Westermarck, Jukka, Xu, Wenqing, DiFeo, Analisa, Brautigan, David L., Haider, Shozeb, Jackson, Mark, Narla, Goutham
Gepubliceerd in Oncogene (2019)

The highly recurrent PP2A Aα-subunit mutation P179R alters protein structure and impairs PP2A enzyme function to promote endometrial tumorigenesis

door Taylor, Sarah E., O’Connor, Caitlin M., Wang, Zhizhi, Shen, Guobo, Song, Haichi, Leonard, Daniel, Sangodkar, Jaya, LaVasseur, Corinne, Avril, Stefanie, Waggoner, Steven, Zanotti, Kristine, Armstrong, Amy J., Nagel, Christa, Resnick, Kimberly, Singh, Sareena, Jackson, Mark W., Xu, Wenqing, Haider, Shozeb, DiFeo, Analisa, Narla, Goutham
Gepubliceerd in Cancer Res (2019)

Selective PP2A enhancement through biased heterotrimer stabilization

door Leonard, Daniel, Huang, Wei, Izadmehr, Sudeh, O’Connor, Caitlin M., Wiredja, Danica D., Wang, Zhizhi, Zaware, Nilesh, Chen, Yinghua, Schlatzer, Daniela M., Kiselar, Janna, Vasireddi, Nikhil, Schüchner, Stefan, Perl, Abbey L., Galsky, Matthew D., Xu, Wenqing, Brautigan, David L., Ogris, Egon, Taylor, Derek J., Narla, Goutham
Gepubliceerd in Cell (2020)

The SRG rat, a Sprague-Dawley Rag2/Il2rg double-knockout validated for human tumor oncology studies

door Noto, Fallon K., Sangodkar, Jaya, Adedeji, Bisoye Towobola, Moody, Sam, McClain, Christopher B., Tong, Ming, Ostertag, Eric, Crawford, Jack, Gao, Xiaohua, Hurst, Lauren, O’Connor, Caitlin M., Hanson, Erika N., Izadmehr, Sudeh, Tohmé, Rita, Narla, Jyothsna, LeSueur, Kristin, Bhattacharya, Kajari, Rupani, Amit, Tayeh, Marwan K., Innis, Jeffrey W., Galsky, Matthew D., Evers, B. Mark, DiFeo, Analisa, Narla, Goutham, Jamling, Tseten Y.
Gepubliceerd in PLoS One (2020)

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth

door Sangodkar, Jaya, Perl, Abbey, Tohme, Rita, Kiselar, Janna, Kastrinsky, David B., Zaware, Nilesh, Izadmehr, Sudeh, Mazhar, Sahar, Wiredja, Danica D., O’Connor, Caitlin M., Hoon, Divya, Dhawan, Neil S., Schlatzer, Daniela, Yao, Shen, Leonard, Daniel, Borczuk, Alain C., Gokulrangan, Giridharan, Wang, Lifu, Svenson, Elena, Farrington, Caroline C., Yuan, Eric, Avelar, Rita A., Stachnik, Agnes, Smith, Blake, Gidwani, Vickram, Giannini, Heather M., McQuaid, Daniel, McClinch, Kimberly, Wang, Zhizhi, Levine, Alice C., Sears, Rosalie C., Chen, Edward Y., Duan, Qiaonan, Datt, Manish, Haider, Shozeb, Ma’ayan, Avi, DiFeo, Analisa, Sharma, Neelesh, Galsky, Matthew D., Brautigan, David L., Ioannou, Yiannis A., Xu, Wenqing, Chance, Mark R., Ohlmeyer, Michael, Narla, Goutham
Gepubliceerd in J Clin Invest (2017)