Selective PP2A enhancement through biased heterotrimer stabilization

Impairment of protein phosphatases, including the family of serine/threonine phosphatases designated PP2A, is essential for the pathogenesis of many diseases, including cancer. The ability of PP2A to dephosphorylate hundreds of proteins is regulated by over 40 specificity-determining regulatory “B”...

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Publicado no:Cell
Main Authors: Leonard, Daniel, Huang, Wei, Izadmehr, Sudeh, O’Connor, Caitlin M., Wiredja, Danica D., Wang, Zhizhi, Zaware, Nilesh, Chen, Yinghua, Schlatzer, Daniela M., Kiselar, Janna, Vasireddi, Nikhil, Schüchner, Stefan, Perl, Abbey L., Galsky, Matthew D., Xu, Wenqing, Brautigan, David L., Ogris, Egon, Taylor, Derek J., Narla, Goutham
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7243596/
https://ncbi.nlm.nih.gov/pubmed/32315618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.03.038
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