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Reengineered tricyclic anti-cancer agents
The phenothiazine and dibenzazepine tricyclics are potent neurotropic drugs with a documented but underutilized anti-cancer side effect. Reengineering these agents (TFP, CPZ, CIP) by replacing the basic amine with a neutral polar functional group (e.g., RTC-1, RTC-2) abrogated their CNS effects as d...
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| Vydáno v: | Bioorg Med Chem |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8293910/ https://ncbi.nlm.nih.gov/pubmed/26372073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.07.007 |
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