Reengineered tricyclic anti-cancer agents

The phenothiazine and dibenzazepine tricyclics are potent neurotropic drugs with a documented but underutilized anti-cancer side effect. Reengineering these agents (TFP, CPZ, CIP) by replacing the basic amine with a neutral polar functional group (e.g., RTC-1, RTC-2) abrogated their CNS effects as d...

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Detaylı Bibliyografya
Yayımlandı:Bioorg Med Chem
Asıl Yazarlar: Kastrinsky, David B., Sangodkar, Jaya, Zaware, Nilesh, Izadmehr, Sudeh, Dhawan, Neil S., Narla, Goutham, Ohlmeyer, Michael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8293910/
https://ncbi.nlm.nih.gov/pubmed/26372073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.07.007
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