Selective PP2A enhancement through biased heterotrimer stabilization

Impairment of protein phosphatases, including the family of serine/threonine phosphatases designated PP2A, is essential for the pathogenesis of many diseases, including cancer. The ability of PP2A to dephosphorylate hundreds of proteins is regulated by over 40 specificity-determining regulatory “B”...

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Published in:Cell
Main Authors: Leonard, Daniel, Huang, Wei, Izadmehr, Sudeh, O’Connor, Caitlin M., Wiredja, Danica D., Wang, Zhizhi, Zaware, Nilesh, Chen, Yinghua, Schlatzer, Daniela M., Kiselar, Janna, Vasireddi, Nikhil, Schüchner, Stefan, Perl, Abbey L., Galsky, Matthew D., Xu, Wenqing, Brautigan, David L., Ogris, Egon, Taylor, Derek J., Narla, Goutham
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7243596/
https://ncbi.nlm.nih.gov/pubmed/32315618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.03.038
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