Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann–Pick C1-deficient cells

We investigated intracellular trafficking of GM1 ganglioside in Niemann–Pick C1 (NPC1)-deficient Chinese hamster ovary cells [NPC1(−) cells] by using cholera toxin (CT) as a probe. Both the holotoxin and the B subunit (CTB) accumulated in GM1-enriched intracellular vesicles of NPC1(−) cells. CTB-lab...

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Detalhes bibliográficos
Main Authors: Sugimoto, Yuko, Ninomiya, Haruaki, Ohsaki, Yuki, Higaki, Katsumi, Davies, Joanna P., Ioannou, Yiannis A., Ohno, Kousaku
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC60064/
https://ncbi.nlm.nih.gov/pubmed/11675488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.221181998
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