Endosomal Accumulation of Toll-Like Receptor 4 Causes Constitutive Secretion of Cytokines and Activation of Signal Transducers and Activators of Transcription in Niemann–Pick Disease Type C (NPC) Fibroblasts: A Potential Basis for Glial Cell Activation in the NPC Brain

Niemann–Pick disease type C (NPC) is an inherited lipid storage disorder caused by mutations in NPC1 or NPC2 genes. Loss of function of either protein results in the endosomal accumulation of cholesterol and other lipids, progressive neurodegeneration, and robust glial cell activation. Here, we repo...

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Vydáno v:J Neurosci
Hlavní autoři: Suzuki, Michitaka, Sugimoto, Yuko, Ohsaki, Yuki, Ueno, Makoto, Kato, Shinsuke, Kitamura, Yukisato, Hosokawa, Hiroshi, Davies, Joanna P., Ioannou, Yiannis A., Vanier, Marie T., Ohno, Kousaku, Ninomiya, Haruaki
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673540/
https://ncbi.nlm.nih.gov/pubmed/17314284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5282-06.2007
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