Endosomal Accumulation of Toll-Like Receptor 4 Causes Constitutive Secretion of Cytokines and Activation of Signal Transducers and Activators of Transcription in Niemann–Pick Disease Type C (NPC) Fibroblasts: A Potential Basis for Glial Cell Activation in the NPC Brain

Niemann–Pick disease type C (NPC) is an inherited lipid storage disorder caused by mutations in NPC1 or NPC2 genes. Loss of function of either protein results in the endosomal accumulation of cholesterol and other lipids, progressive neurodegeneration, and robust glial cell activation. Here, we repo...

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Bibliografiset tiedot
Julkaisussa:J Neurosci
Päätekijät: Suzuki, Michitaka, Sugimoto, Yuko, Ohsaki, Yuki, Ueno, Makoto, Kato, Shinsuke, Kitamura, Yukisato, Hosokawa, Hiroshi, Davies, Joanna P., Ioannou, Yiannis A., Vanier, Marie T., Ohno, Kousaku, Ninomiya, Haruaki
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Society for Neuroscience 2007
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673540/
https://ncbi.nlm.nih.gov/pubmed/17314284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5282-06.2007
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