Endosomal Accumulation of Toll-Like Receptor 4 Causes Constitutive Secretion of Cytokines and Activation of Signal Transducers and Activators of Transcription in Niemann–Pick Disease Type C (NPC) Fibroblasts: A Potential Basis for Glial Cell Activation in the NPC Brain

Niemann–Pick disease type C (NPC) is an inherited lipid storage disorder caused by mutations in NPC1 or NPC2 genes. Loss of function of either protein results in the endosomal accumulation of cholesterol and other lipids, progressive neurodegeneration, and robust glial cell activation. Here, we repo...

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Detaylı Bibliyografya
Yayımlandı:J Neurosci
Asıl Yazarlar: Suzuki, Michitaka, Sugimoto, Yuko, Ohsaki, Yuki, Ueno, Makoto, Kato, Shinsuke, Kitamura, Yukisato, Hosokawa, Hiroshi, Davies, Joanna P., Ioannou, Yiannis A., Vanier, Marie T., Ohno, Kousaku, Ninomiya, Haruaki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Society for Neuroscience 2007
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673540/
https://ncbi.nlm.nih.gov/pubmed/17314284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5282-06.2007
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