Slow thrombin in solution

por Huntington, James A.
Publicado 2005

SLOW THROMBIN IS ZYMOGEN-LIKE

por Huntington, James A.
Publicado 2009

How Na(+) Activates Thrombin – A Review of the Functional and Structural Data

por Huntington, James A.
Publicado 2008

Structural transitions during prothrombin activation: On the importance of fragment 2

por Adams, Ty E., Huntington, James A.
Publicado en Biochimie (2016)

Ligand Binding Shuttles Thrombin along a Continuum of Zymogen- and Proteinase-like States

por Kamath, Parvathi, Huntington, James A., Krishnaswamy, Sriram
Publicado 2010

Identification of serpins specific for activated protein C using a lysate-based screening assay

por Polderdijk, Stéphanie G. I., Huntington, James A.
Publicado en Sci Rep (2018)

New insight into serpin polymerization and aggregation

por Huntington, James A, Sendall, Timothy J, Yamasaki, Masayuki
Publicado 2009

Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-Å structure of the ternary complex

por Johnson, Daniel J. D., Langdown, Jonathan, Huntington, James A.
Publicado 2010

GpIbα Interacts Exclusively with Exosite II of Thrombin()

por Lechtenberg, Bernhard C., Freund, Stefan M.V., Huntington, James A.
Publicado 2014

Targeting activated protein C to treat hemophilia

por Polderdijk, Stéphanie G.I., Baglin, Trevor P., Huntington, James A.
Publicado en Curr Opin Hematol (2017)

A hereditary bleeding disorder resulting from a premature stop codon in thrombomodulin (p.Cys537Stop)

por Langdown, Jonathan, Luddington, Roger J., Huntington, James A., Baglin, Trevor P.
Publicado 2014

Crystal structure of wild-type human thrombin in the Na(+)-free state

por Johnson, Daniel J. D., Adams, Ty E., Li, Wei, Huntington, James A.
Publicado 2005

Antithrombin–S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation

por Johnson, Daniel J D, Li, Wei, Adams, Ty E, Huntington, James A
Publicado 2006

Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-Å structure of the heparin-bridged complex

por Li, Wei, Adams, Ty E., Nangalia, Jyoti, Esmon, Charles T., Huntington, James A.
Publicado 2008

Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism

por Baglin, Trevor P., Carrell, Robin W., Church, Frank C., Esmon, Charles T., Huntington, James A.
Publicado 2002

The Critical Role of Hinge Region Expulsion in the Induced-fit Heparin Binding Mechanism of Antithrombin

por Langdown, Jonathan, Belzar, Klara J., Savory, Wendy J., Baglin, Trevor P., Huntington, James A.
Publicado 2009

NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation

por Lechtenberg, Bernhard C., Johnson, Daniel J. D., Freund, Stefan M. V., Huntington, James A.
Publicado 2010

Molecular basis of α(1)-antitrypsin deficiency revealed by the structure of a domain-swapped trimer

por Yamasaki, Masayuki, Sendall, Timothy J, Pearce, Mary C, Whisstock, James C, Huntington, James A
Publicado 2011

Loop-Sheet Mechanism of Serpin Polymerization Tested by Reactive Center Loop Mutations

por Yamasaki, Masayuki, Sendall, Timothy J., Harris, Laura E., Lewis, Giles M. W., Huntington, James A.
Publicado 2010

The Shapes of Z-α(1)-Antitrypsin Polymers in Solution Support the C-Terminal Domain-Swap Mechanism of Polymerization

por Behrens, Manja A., Sendall, Timothy J., Pedersen, Jan S., Kjeldgaard, Morten, Huntington, James A., Jensen, Jan K.
Publicado 2014