Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism
The serine proteases sequentially activated to form a fibrin clot are inhibited primarily by members of the serpin family, which use a unique β-sheet expansion mechanism to trap and destroy their targets. Since the discovery that serpins were a family of serine protease inhibitors there has been con...
Kaydedildi:
| Yayımlandı: | Proc Natl Acad Sci U S A |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2002
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123213/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12169660/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.162232399 |
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