Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism

The serine proteases sequentially activated to form a fibrin clot are inhibited primarily by members of the serpin family, which use a unique β-sheet expansion mechanism to trap and destroy their targets. Since the discovery that serpins were a family of serine protease inhibitors there has been con...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Baglin, Trevor P., Carrell, Robin W., Church, Frank C., Esmon, Charles T., Huntington, James A.
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2002
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123213/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12169660/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.162232399
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