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Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism
The serine proteases sequentially activated to form a fibrin clot are inhibited primarily by members of the serpin family, which use a unique β-sheet expansion mechanism to trap and destroy their targets. Since the discovery that serpins were a family of serine protease inhibitors there has been con...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC123213/ https://ncbi.nlm.nih.gov/pubmed/12169660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.162232399 |
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