The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.

Protein C activation on the surface of the endothelium is critical to the negative regulation of blood coagulation. We now demonstrate that monoclonal antibodies that block protein C binding to the endothelial cell protein C receptor (EPCR) reduce protein C activation rates by the thrombin-thrombomo...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Stearns-Kurosawa, D J, Kurosawa, S, Mollica, J S, Ferrell, G L, Esmon, C T
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38363/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8816778/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.19.10212
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