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NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation
The serine protease thrombin is generated from its zymogen prothrombin at the end of the coagulation cascade. Thrombin functions as the effector enzyme of blood clotting by cleaving several procoagulant targets, but also plays a key role in attenuating the hemostatic response by activating protein C...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922568/ https://ncbi.nlm.nih.gov/pubmed/20660315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005255107 |
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