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NMR reveals a dynamic allosteric pathway in thrombin

Although serine proteases are found ubiquitously in both eukaryotes and prokaryotes, and they comprise the largest of all of the peptidase families, their dynamic motions remain obscure. The backbone dynamics of the coagulation serine protease, apo-thrombin (S195M-thrombin), were compared to the sub...

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Publicado en:Sci Rep
Autores principales: Handley, Lindsey D., Fuglestad, Brian, Stearns, Kyle, Tonelli, Marco, Fenwick, R. Bryn, Markwick, Phineus R. L., Komives, Elizabeth A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216386/
https://ncbi.nlm.nih.gov/pubmed/28059082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39575
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