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NMR reveals a dynamic allosteric pathway in thrombin
Although serine proteases are found ubiquitously in both eukaryotes and prokaryotes, and they comprise the largest of all of the peptidase families, their dynamic motions remain obscure. The backbone dynamics of the coagulation serine protease, apo-thrombin (S195M-thrombin), were compared to the sub...
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Publicado en: | Sci Rep |
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Autores principales: | , , , , , , |
Formato: | Artigo |
Lenguaje: | Inglês |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5216386/ https://ncbi.nlm.nih.gov/pubmed/28059082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39575 |
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