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Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities
The serine protease α-thrombin is a dual-action protein that mediates the blood-clotting cascade. Thrombin alone is a procoagulant, cleaving fibrinogen to make the fibrin clot, but the thrombin–thrombomodulin (TM) complex initiates the anticoagulant pathway by cleaving protein C. A TM fragment consi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3535651/ https://ncbi.nlm.nih.gov/pubmed/23197839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218414109 |
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