The Dynamic Structure of Thrombin in Solution

The backbone dynamics of human α-thrombin inhibited at the active site serine were analyzed using R(1), R(2), and heteronuclear NOE experiments, variable temperature TROSY 2D [(1)H-(15)N] correlation spectra, and R(ex) measurements. The N-terminus of the heavy chain, which is formed upon zymogen act...

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Detalhes bibliográficos
Main Authors: Fuglestad, Brian, Gasper, Paul M., Tonelli, Marco, McCammon, J. Andrew, Markwick, Phineus R.L., Komives, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2012
Assuntos:
Molecular Machines, Motors, and Nanoscale Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388214/
https://ncbi.nlm.nih.gov/pubmed/22828334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.05.047
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