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Ligand Binding Shuttles Thrombin along a Continuum of Zymogen- and Proteinase-like States
The critical and multiple roles of thrombin in blood coagulation are regulated by ligands and cofactors. Zymogen activation imparts proteolytic activity to thrombin and also affects the binding of ligands to its two principal exosites. We have used the activation peptide fragment 1.2 (F12), a ligand...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2937891/ https://ncbi.nlm.nih.gov/pubmed/20639195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.154914 |
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