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Meizothrombin Is an Unexpectedly Zymogen-like Variant of Thrombin

Thrombin is produced by the ordered action of prothrombinase on two cleavage sites in prothrombin. Meizothrombin, a proteinase precursor of thrombin, is a singly cleaved species that accumulates abundantly as an intermediate. We now show that covalent linkage of the N-terminal propiece with the prot...

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Autors principals: Bradford, Harlan N., Krishnaswamy, Sriram
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436291/
https://ncbi.nlm.nih.gov/pubmed/22815477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.394809
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