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Occlusion of anion-binding exosite 2 in meizothrombin explains its impaired ability to activate factor V

The proteolytic conversion of factor V to factor Va is central for amplified flux through the blood coagulation cascade. Heterodimeric factor Va is produced by cleavage at three sites in the middle of factor V by thrombin, yielding an N terminus–derived heavy chain and a C terminus–derived light cha...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Bradford, Harlan N., Krishnaswamy, Sriram
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6378960/
https://ncbi.nlm.nih.gov/pubmed/30578302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006510
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