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Membrane Binding by Prothrombin Mediates Its Constrained Presentation to Prothrombinase for Cleavage
Long-standing dogma proposes a profound contribution of membrane binding by prothrombin in determining the rate at which it is converted to thrombin by prothrombinase. We have examined the action of prothrombinase on full-length prothrombin variants lacking γ-carboxyglutamate modifications (desGla)...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3784695/ https://ncbi.nlm.nih.gov/pubmed/23940050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.502005 |
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