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Membrane Binding by Prothrombin Mediates Its Constrained Presentation to Prothrombinase for Cleavage

Long-standing dogma proposes a profound contribution of membrane binding by prothrombin in determining the rate at which it is converted to thrombin by prothrombinase. We have examined the action of prothrombinase on full-length prothrombin variants lacking γ-carboxyglutamate modifications (desGla)...

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Bibliografiske detaljer
Main Authors: Bradford, Harlan N., Orcutt, Steven J., Krishnaswamy, Sriram
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784695/
https://ncbi.nlm.nih.gov/pubmed/23940050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.502005
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