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Restricted Active Site Docking by Enzyme-bound Substrate Enforces the Ordered Cleavage of Prothrombin by Prothrombinase

The preferred pathway for prothrombin activation by prothrombinase involves initial cleavage at Arg(320) to produce meizothrombin, which is then cleaved at Arg(271) to liberate thrombin. Exosite binding drives substrate affinity and is independent of the bond being cleaved. The pathway for cleavage...

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Detalhes bibliográficos
Main Authors: Hacisalihoglu, Ayse, Panizzi, Peter, Bock, Paul E., Camire, Rodney M., Krishnaswamy, Sriram
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292459/
https://ncbi.nlm.nih.gov/pubmed/17848548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M706529200
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