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Restricted Active Site Docking by Enzyme-bound Substrate Enforces the Ordered Cleavage of Prothrombin by Prothrombinase

The preferred pathway for prothrombin activation by prothrombinase involves initial cleavage at Arg(320) to produce meizothrombin, which is then cleaved at Arg(271) to liberate thrombin. Exosite binding drives substrate affinity and is independent of the bond being cleaved. The pathway for cleavage...

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Autori principali: Hacisalihoglu, Ayse, Panizzi, Peter, Bock, Paul E., Camire, Rodney M., Krishnaswamy, Sriram
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292459/
https://ncbi.nlm.nih.gov/pubmed/17848548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M706529200
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