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Fate of Membrane-bound Reactants and Products during the Activation of Human Prothrombin by Prothrombinase
Membrane binding by prothrombin, mediated by its N-terminal fragment 1 (F1) domain, plays an essential role in its proteolytic activation by prothrombinase. Thrombin is produced in two cleavage reactions. One at Arg(320) yields the proteinase meizothrombin that retains membrane binding properties. T...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2573076/ https://ncbi.nlm.nih.gov/pubmed/18765660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806158200 |
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