Carregant...
Occlusion of anion-binding exosite 2 in meizothrombin explains its impaired ability to activate factor V
The proteolytic conversion of factor V to factor Va is central for amplified flux through the blood coagulation cascade. Heterodimeric factor Va is produced by cleavage at three sites in the middle of factor V by thrombin, yielding an N terminus–derived heavy chain and a C terminus–derived light cha...
Guardat en:
| Publicat a: | J Biol Chem |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6378960/ https://ncbi.nlm.nih.gov/pubmed/30578302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006510 |
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