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Exosite binding drives substrate affinity for the activation of coagulation factor X by the intrinsic Xase complex
Factor X activation by the intrinsic Xase complex, composed of factor IXa bound to factor VIIIa on membranes, is essential for the amplified blood coagulation response. The biological significance of this step is evident from bleeding arising from deficiencies in factors VIIIa or IXa in hemophilia....
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| Publicado no: | J Biol Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7650255/ https://ncbi.nlm.nih.gov/pubmed/32859749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015325 |
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