Unexpected Dynamic Binding May Rescue the Binding Affinity of Rivaroxaban in a Mutant of Coagulation Factor X

A novel coagulation factor X (FX) Tyr319Cys mutation (Y99C as chymotrypsin numbering) was identified in a patient with severe bleeding. Unlike the earlier reported Y99A mutant, this mutant can bind and cleave its specific chromogenetic substrate at a normal level, suggesting an intact binding pocket...

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Main Authors: Zhi-Li Zhang, Changming Chen, Si-Ying Qu, Qiulan Ding, Qin Xu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Molecular Biosciences
Assuntos:
coagulation factors
rivaroxaban
molecular dynamics simulations
molecular flexibility
structure-based drug design
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fmolb.2022.877170/full
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